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Molecular Plant Advance Access published online on March 31, 2009
Molecular Plant, doi:10.1093/mp/ssp019
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© The Author 2009. Published by the Molecular Plant Shanghai Editorial Office in association with Oxford University Press on behalf of CSPP and IPPE, SIBS, CAS.

The Beauty of Being a Variant: H2A.Z and the SWR1 Complex in Plants

Rosana March-Díaz and Jose C. Reyes1

Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), CSIC, Américo Vespucio s/n, E-41092 Sevilla, Spain

1 To whom correspondence should be addressed. E-mail jose.reyes{at}cabimer.es.

Numerous studies have shown that the nucleosome is a dynamic structure that strongly influences gene expression. Dynamism concerns different nucleosomal characteristics, including position, posttranslational modifications, and histone composition. Thus, within the nucleosome, canonical histones can be exchanged by histone variant proteins with specific functions—a process known as ‘histone replacement’. The histone variant H2A.Z has an important function in transcription and, during the last few years, its role in plant development and immune response has become evident. Compiling genetic and biochemical studies from several laboratories has revealed that plants contain a multiprotein complex, similar to the SWR1/SRCAP complex from yeast and animals, involved in H2A.Z deposition. Despite intense research in different organisms, the mechanism by which H2A.Z influences transcription is still unknown. However, recent results from Arabidopsis have shown a strong inverse correlation between H2A.Z and DNA methylation, suggesting that H2A.Z might protect genes from silencing.

Key Words: Chromatin structure and remodeling • epigenetics • gene regulation • floral induction


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